Rumex spp. is the major broad-leaf weed of irrigated wheat. Manual weeding is not feasible in wheat crop sown with a narrow spacing and weed management thus is accomplished through application of herbicides. The poor efficacy of otherwise effective herbicides so far against this weed has come to the fore indicating the likelihood of herbicide resistance. Hence, the present study was carried out during Rabi of 2017-18 at screen house of College of Agriculture, Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana, India to evaluate herbicide resistance in Rumex spp. and its management in wheat crop using four test populations of Rumex spp. named as HHH (HAU Hisar), UPH (Ujha, Panipat), JHH (Jind), and JJR (Jhajjar). Three herbicides - carfentrazone, mesosulfuron + iodosulfuron and 2,4-D ester at three doses (0.5X, X and 2.0X) with one unsprayed control were taken as treatments in the pot experiment under completely randomised design (CRD) replicated thrice. Results indicated that all the populations have attained resistance against mesosulfuron + iodosulfuron even at double of the recommended dose. Higher values of plant height, chlorophyll fluorescence, dry weight and lower value of electrical conductivity was observed in mesosulfuron + iodosulfuron treated plants. Carfentrazone provided moderate control to all populations even at double of the recommended dose. The application of 2,4-D ester at double of the recommended doses provided 77-100% control of all populations except UPH where lower efficacy continued even at double dose. Resistance thus confirmed in Rumex dentatus requiring alternate herbicides for field level effective management.