A field study was conducted under arid climatic conditions at Agricultural Research Station, Mandor, Jodhpur, Rajasthan, India, during rainy season (Kharif) of 2018, 2019 and 2020. The aim of this study was to identify effective and profitable weed management practices in groundnut for managing weeds and improve groundnut productivity. The weed density and biomass were reduced significantly with hand weeding twice at 20 and 40 days after sowing (DAS). Next best treatment was pendimethalin 30 EC + imazethapyr 2 EC (ready mix) 1.0 kg/ha pre-emergence application (PE) followed by (fb) manual weeding at 30 DAS. The highest weed control efficiency (87.48%) and herbicide efficiency index (4.66%) were also recorded with manual weeding twice at 20 and 40 DAS. Next best treatment was pendimethalin + imazethapyr (ready mix) 1.0 kg/ha PE fb manual weeding at 30 DAS in terms of lower weed density and biomass, higher weed control efficiency and herbicide efficiency index. The groundnut pod (2.12 t/ha) and haulm yield (3.89 t/ha) were highest with manual weeding twice at 20-40 DAS. All the weed management treatments did not influence the oil content. The highest net returns ( 36033 /ha) and B: C ratio (1.57) were obtained with pendimethalin 1.0 kg/ha PE fb imazethapyr 75 g/ha post-emergence application (PoE) at 20 DAS.