Weeds cause drastic reduction of rice yield and quality. The weeds problem is more severe in upland rice system. The efficiency and economics of different weed management treatments on weed dynamics, yield and economics of upland rice were evaluated by carrying out field experiment during rainy season of 2017 at NARC research station, Dasarathpur, Surkhet, Nepal. The experiment consisted of six treatments, viz: control, farmers’ practice of hand weeding (HW) twice at15 and 30 days after seeding (DAS), manually running dry land weeder twice 15 and 30 DAS, one HW at 15 DAS fb bispyribac-sodium post-emergence application (PoE) at 0.4 g/ha 30 DAS, pre-emergence application (PE) of pendimethalin 1.5 g/ha fb 1 HW 15 DAS and pendimethalin PE at 1.5 g/ha fb bispyribac-sodium PoE 0.4 g/ha 15 DAS, were tested in one factor RCBD design with four replications. Pendimethalin PE 1.5 g/ha fb bispyribac-sodium PoE 0.4 g/ha 15 DAS was found to be most efficient and economical weed management option in upland rice with the highest rice grain yield (2.63 t/ha), net returns and B:C ratio.