An experiment was conducted during Rabi season of 2008-09 and 2009-10 at Varanasi (Uttar Pradesh) to evaluate the boiefficacy of carfentrazone-ethyl + sulfosulfuron in wheat. The experimental field was infested with Phalaris minor, Rumex dentatus, Chenopodium album, Anagalis arvensis and Melilotus spp during both the years of study. The result indicated that post-emergence application of carfentrazone + sulfosulfuron with surfactant at 45 g/ha recorded minimum density and dry weight of weeds and it was at par to 54 and 90 g/ha, without any phytotoxicity symptoms on the crop. Significant variation in wheat yield was recorded due to application of different herbicides when compared with control. Carfentrazone-ethyl + sulfosulfuron with surfactant at 45 g/ha recorded significantly the highest grain yield over its rate of 36 g/ha and it was at par to 54 and 90 g/ha. The regration equation indicated that extent of reduction could be 26.5 kg/ha for weed dry weight. The evaluation of weed dry weight and weed control efficiency of the different treatments and the regression of yield on it reveled that reduction in grain yield could be 0.025 t/ha for weed dry weight and 1% increase in the weed control efficiency increased the grain yield by 0.020 t/ha, respectively.