A field experiment was conducted at Cotton Research Station, (TNAU), Srivilliputtur under winter irrigated condition from September 2020 to February 2021. The objective of the study was to identify a suitable intercropping system with higher weed smothering efficiency and cotton productivity. The experiment was carried out in a randomized block design with ten treatments replicated thrice. The weed density and biomass were reduced by all the intercropping systems when compared to sole cropping. Among the intercrops, cluster bean, blackgram and greengram were more efficient in reducing the weed density than onion and coriander. The seed cotton equivalent yield was highest with intercropping of paired row planted Bt cotton with one row each of onion and cluster bean (3.75 t/ha) followed by two rows of cluster bean (3.70 t/ha) and two rows of onion intercropping (3.69 t/ha) as compared sole cotton (2.39 t/ha), cotton + blackgram (2.55 t/ha) and cotton + greengram intercropping system (2.56 t/ha).