A field experiment was carried out during rainy (Kharif) season 2019 at agricultural research farm of Trihut College of Agriculture (TCA), Dholi under Rajendra Prasad Central Agricultural University (RPCAU) Pusa, Samastipur, Bihar, (India) to quantify the efficacy of sole and sequential application of herbicides in managing weeds and enhance the productivity of maize (Zea mays L.). Eleven treatments were tested in randomised block design with three replications. Atrazine 1.0 kg/ha pre-emergence application (PE) followed by (fb) post-emergence application (PoE) of tembotrione 0.120 kg/ha at 25 days after seeding (DAS) significantly reduced weed density, weed biomass, N, P, K removal by weeds and increased the yield attributes, grain yield and benefit-cost ratio of maize compared to sole and tank mixed application of atrazine, topramezone and tembotrione.