A field experiment was conducted in sandy loam soils at College of Agriculture, Professor Jayashankar Telangana State Agricultural University, Hyderabad, during winter (Rabi) season 2020-21. The objective was to study the effect of integration of inter-cultivation with pre- and post-emergence application of herbicides and manual weeding on weeds growth and yield of groundnut. A randomized block design, replicated thrice was used with ten treatments. The broad-spectrum weed control, lower weed biomass, higher weed control efficiency, higher groundnut pod and haulm yield were obtained with inter-cultivation followed by (fb) hand weeding at 20 and 40 days after sowing (DAS). The herbicides based integration revealed the greater weed management efficacy of pre-emergence application (PE) of diclosulam at 26 g/ha fb inter-cultivation at 20 DAS. The next best options for higher WCE and pod yield were imazethapyr + pendimethalin (ready-mix) at 960 g/ha PE fb inter-cultivation at 20 DAS and sodium acifluorfen + clodinofop- propargyl 250 g/ha fb inter-cultivation at 40 DAS.