A field experiment was conducted during rainy seasons of 2018 and 2019 at the ICAR-Research Complex for Eastern Region Patna, Bihar to evaluate the effect of crop establishment methods and weed management treatments on weeds and productivity of direct-seeded rice (DSR). The treatments consisted of three upland DSR establishment methods, viz. zero-till direct-seeded rice:(ZT-DSR); conventional-till (CT)-dry DSR (CTDSR) and CTDSR-dust mulching, and three weed pressure maintenance treatments including: low weed pressure: maintained with pre-emergence (PE) application of pendimethalin (1.0 kg/ha) at 2 days after seeding (DAS) followed by (fb) post-emergence (PoE) application of bispyribac–Na (30 g/ha) PoE at 20 DAS fb hand weeding (HW) twice at 30 and 50 DAS; medium weed pressure: maintained with pendimethalin (1.0 kg/ha) PE at 2 DAS fb bispyribac–Na (30 g/ha) PoE at 20 DAS, and high weed pressure: maintained with pendimethalin (1.0 kg/ha) PE alone, in upland DSR under the middle Indo-Gangetic Plains (MIGPs). The major weeds recorded with upland DSR were Cyperus rotundus, Cynodon dactylon, Echinochloa colona, Brachiaria ramosa, Caesulia axillaris and Physalis minima. Significantly the lowest relative weed abundance, weed density and biomass were recorded in CT-DSR-dust mulching compared to ZT-DSR and CTDSR. Among the weed management treatment, maximum weed suppression was recorded in low weed pressure in comparison to medium and high-weed pressure management practices. Significantly higher grain yield (2.14 t/ha) and net returns ( 20869/ha) were obtained with CT-DSR-dust mulching. Hence, it may be concluded that for better rice productivity and weed management in upland DSR, CT-DSR-dust mulching with low weed pressure maintenance is the most potential and viable practices under the MIGPs.