A field experiment on effect of tillage and weed management on weed dynamics and yield of rice in rice-wheat-greengram cropping system in vertisols of central India was conducted during Kharif 2014 to 2015 at ICAR-DWR, Jabalpur. The experiment consisted of total 15 treatments. A split plot design having three replications was used with five tillage practices in main plots and three weed control treatments in subplots. The maximum weed density and biomass were found when zero tillage was done in rice in the presence of Sesbania (S) and greengram residues (ZT+S+GG); under zero tillage in rice in the presence of Sesbania and green gram residues-zero tillage in wheat in the presence of rice residues- zero tillage in greengram in the presence of wheat residues system [ZT+S+GG(R)-ZT+RR(W)-ZT+WR(GG)] followed by zero tillage done in rice in the presence of only Sesbania residues (ZT+S) under ZT+S(R)-ZT(W)-ZT(GG) system. Whereas the minimum was recorded when conventional tillage was done in transplanted rice under CT(TPR)-CT(W)-fallow system which also recorded higher grain and straw yields as well as gross monetary returns but had higher cost of cultivation followed by (ZT+S) under ZT+S(R)-ZT(W)-ZT(GG) system. This system also has the maximum net monetary returns and B:C along with the reduced cost of cultivation. Rotational application of chlorimuron + metsulfuron-methyl 4 g /ha during previous year and post-emergence application (PoE) of bispyribac-sodium 25 g/ha during next year in rice as well as regular application of bispyribac-sodium 25 g/ha PoE in rice during both the years gave similar weed control and recorded the higher crop yield, net monetary returns and B:C. Among different treatment combinations, rotational application of chlorimuron + metsulfuron-methyl 4 g/ha PoE during previous year and bispyribac-sodium 25 g/ha PoE during next year after conventional tillage in transplanted rice under CT(TPR)-CT(W)-fallow system and ZT+S in rice under ZT+S(R)-ZT(W)-ZT(GG) system has resulted lower weed density and biomass along with higher weed control efficiency, higher grain and straw yields and economic returns than other combinations.