Field experiment was carried during summer 2020 at Agronomy farm, B. A. College of Agriculture, Anand Agricultural University, Anand, Gujarat on loamy sand soil to study the effect of herbicide mixtures on weeds and yield of summer groundnut (Arachis hypogaea L.). The experiment was conducted in randomized block design with twelve treatments, replicated four times. Weed density decreased significantly with pre-emergence application (PE) of  pendimethalin + oxyfluorfen (tank mix) 900 + 120 g/ha and intercultivation (IC) followed by (fb) hand weeding (HW) at 20 and 50 days after seeding (DAS), as compared to other treatments, which resulted in significant increase in growth and yield attributes viz., periodical plant height (cm), plant dry biomass (g/plant), nodule dry weight (mg/plant), number of pods/ plant, pod yield (kg/ha), haulm yield (kg/ha), seed index (g), harvest index (%) and shelling percentage (%). Maximum net returns (Rs. 125485/ha) and B:C (4.94) was achieved with  pendimethalin  + oxyfluorfen  900 + 120 g/ha PE which was closely followed by IC fb HW at 20 and 50 DAS and early post-emergence application of fluazifop-p-butyl (11.1%) + fomesafen (11.1%) SL (pre-mix) 250 g/ha.