Weed control is an important component of crop management as it determines the crops productivity, quality and the profitability. A field trial was conducted in 2019 rainy season at Research and Training Farm of Centre for Dryland Agriculture, Bayero University Kano (BUK) (11°58'52.5" N and 008°24'48.6") and National Horticultural Research Institute at Bagauda, Kano (11°33’25.93" N and 008°23’11.97" E), Nigeria. The experiment was aimed at evaluating weed management strategies effect on quality and profitability of sesame production. Eleven weed management treatments were laid out in randomized complete block design replicated thrice. Weedy check recorded the largest number of broad-leaved, grasses and sedges weed species in both locations. The pre-emergence application (PE) of pendimethalin followed by (fb) a hoe weeding at 6 weeks after seeding (WAS) recorded the highest sesamum seed yield, seed oil contents and physical purity when compared to other weed control treatments at both locations. Hoe weeding twice at 3 and 6 WAS had the highest seed yield (1223 kg/ha and 1212 kg/ha), total variable cost ($973 and $963) and gross revenues ($1065 and $1056) than other weed control treatments, at both the locations. Hoe weeding twice at 3 and 6 WAS resulted into higher seed yield, but it is not economical due to labour cost involved. Pendimethalin 1.0kg/ha PE fb post-emergence application (PoE) of Tithonia diversifolia (Hemsl.) A. Gray leaf extract 5% w/v at 6 WAS had higher net return ($309 and $317) and benefit cost ratio (1.50 and 1.52) proving to be more economical and could therefore be recommended in the study area.