A field experiment was conducted at S.V. Agricultural College Farm, Tirupati to identify the effective and economic weed management practices for the control of weeds in drum seeded rice. The major weed flora in experiment field were Cyperus difformis (40.0%), Cyperus iria (21.40%), Cyperus rotundus (12.22 %), Echinochloa colonum (10.1%), Eclipta alba (6.5%) and Ammania baccifera (4%). Among the weed management practices, pre-emergence application of oxadiargyl 75 g/ha fb azimsulfuron 30 g/ha was found to be the most effective weed management practice in reducing the density and dry weight of weeds with higher weed control efficiency, higher yield attributes and yield (5.75 t/ha) including benfit : cost ratio (3.30) but it was being at par with two hand weedings. The reduction in grain yield due to heavy weed infestation in unweeded check was 51% compared to best weed management practice. Post-emergence application of azimsulfuron 30 g/ha was found effective in controlling sedges and bispyribac-sodium 30 g/ha was very effective in suppressing the grasses and broad-leaved weeds in drum seeded rice.