A field experiment was carried out during two consecutive Kharif-Rabi seasond of  2019-20 and 2020-21 at AICRP Weed Management Farm, B. A. College of Agriculture, Anand Agricultural University, Anand to evaluate the effect of pre-emergence application (PE) (next day after planting) of atrazine 750 g/ha, metribuzin 500 g/ha, pendimethalin 750 g/ha and atrazine 500 g/ha + pendimethalin 500 g/ha (tank-mix) followed by (fb) rice straw mulch 5 t/ha (one day after application of PE) fb hand weeding (HW) at 75 days after planting (DAP) and interculturing (IC) fb HW at 20, 40 and 60 DAP and earthing up at 75 DAP on weed control, rhizome yield and economics of turmeric on loamy sand soil. Atrazine 500 g/ha + pendimethalin 500 g/ha (tank-mix) PE fb rice straw mulch 5 t/ha (0-3 DAP) fb HW at 75 DAP provided effective control of weeds with higher weed control efficiency and higher rhizome yield with better economic returns. The next best treatment was metribuzin 750 g/ha PE fb rice straw mulch 5 t/ha fb HW at 75 DAP during both the years.