In order to assess the impact of various tillage and weed management practices on the weed dynamics and productivity of rainfed pearl millet [Pennisetum glaucum (L.) R. Br] under conservation agriculture, an experiment was carried out in 2019–20 at ICAR–IARI, New Delhi. Adoption of zero tillage + barley residue retention 3 t/ha (ZT + R) increased the pearl millet grain yield by 9.17 and 13.3%, respectively over the zero tillage (ZT) and conventional tillage (CT). At 60 days after sowing (DAS), hand weeding (HW) had the highest weed control efficiency (78.3%). Pre-emergence application (PE) of atrazine 0.75 kg/ha fb post-emergence application (PoE) of 2,4-D 0.75 kg/ha was the next successful treatments (77.5%). With HW twice at 30 and 50 DAS, grain yield was considerably higher (2.53 t/ha), and atrazine 0.75 kg/ha PE fb 2,4-D 0.75 kg/ha PoE recorded next highest yield (2.42 t/ha). Atrazine 0.75kg/ha PE fb 2,4-D 0.75 kg/ha PoE recorded significantly greater net returns (Rs 29201) and B:C (1.08).