A field experiment was conducted at AICRP on Weed Management, MRS, Hebbal, Bengaluru during 2020 and 2021 (summer) to study the effect of different conservation tillage and weed management approaches on growth, yield and economics of cultivation of maize. The experiment was laid out in a split-plot design with five main plots of different tillage treatments and three subplots of different weed management practices replicated thrice. The main plot tillage treatments consisted of conventional tillage, zero tillage, minimum tillage, minimum tillage + zero tillage (combination), and permanent raised bed. Among tillage practices, permanent raised bed recorded the least total weed density (64.8 no./m2) and weed dry weight (21.9 g/m2) at 60 DAS, compared to other tillage practices and also high kernel yield, stover yield and B: C ratio 3.20 t/ha, 4.10 t/ha and 1.53, respectively due to less weed infestation, good root growth, adequate aeration, and nutrient availability compared to other tillage practices. The subplot weed management practices consisted of recommended herbicides (pendimethalin-750 g/ha (PE) fb tembotrione 120 g/ha + atrazine 500 g/ha), integrated weed management (pendimethalin-750 g/ha (PE) + hand weeding at 30 DAS) and unweeded check. Among weed management practices, integrated weed management (pendimethalin-750 g/ha (PE) + hand weeding at 30 DAS recorded the least total weed density and  weed dry at 60 DAS compared to unweeded treatment and early 50% tasselling and silking, compared to unweeded treatment and also high kernel yield, stover yield and B: C, 2.94 and 3.49 t/ha, and 1.35 due to less weed infestation, compared to unweeded treatment 1.64 and 2.57 t/ha, and 0.91, respectively.