Cowpea suffers badly due to weed invasion which cause wide range of yield reduction. Therefore, an experiment was planned to determine the effect of different pre- and post-emergence herbicides, stale seedbed techniques and hand weeding in cowpea (Vigna unguiculata L.) during summer season of 2019 and 2020. The average yield losses due to crop-weed competition in cowpea was estimated by 71.32%. The relative density of monocot, dicot and sedges observed in weedy plot were 55.1, 34.3 and 10.6 no./m2, respectively. Plant height, branches/plant, pods/plant and seeds/pod were significantly higher under application of pendimethalin 30 EC 750 g/ha fb HW at 30 DAS, being at par with weed free (HW at 20 and 40 DAS) and pendimethalin 30 EC 750 g/ha fb imazethapyr 10 SL 60 g/ha at 30 DAS. This subsequently produced higher seed (1.37 t/ha) and stover yield (2.07 t/ha) and net return ( 65799/ha) of cowpea. Considering the labour shortage conditions and econiomics, pendimethalin 30 EC 750 g/ha PE fb imazethapyr 10 SL 60 g/ha at 30 DAS ( 64627/ha) was endorsed for weed management to produce comparable cowpea yield with highest B: C ratio (3.17).