The on-farm trial was conducted at Kyrdemkulai village in Ri-Bhoi district of Meghalaya during Kharif  (rainy) season of 2021. The objective of experiment was to compare the effectiveness of manual and mechanical methods of weed management in upland organic rice (ArizeTej Gold). Treatment includes, two-time manual weeding (25-30 days after sowing (DAS) and 45-50 DAS), three times manual weeding (25-30 DAS, 45-50 DAS and 60 DAS), two-time mechanical weeding with the help of manual operated star wheel weeder (23-25 DAS and 45-50 DAS), manual (25-30 DAS) followed by mechanical weeding (45-50 DAS), mechanical (23-25 DAS) followed by manual weeding (45-50 DAS) and two check, viz. weedy check and weed free check. These seven treatments were replicated thrice. Result showed that, three times manual weeding and weed free treatment recorded significantly higher grain yield (5–69%) and net returns (27270 /ha and 27200 /ha, respectively as well as lower weed population by 22-80 no./m2 and 140-220 no./m2, respectively over other treatments. The highest B: C ratio was recorded in mechanical weeding at 23-25 DAS followed by manual weeding at 45-50 DAS (1.50) and three-time manual weeding (1.48). It was concluded that three-time manual weeding will be best due to significantly higher yield (1.74 t/ha); while mechanical weeding  fb manual weeding will be considered economic with B:C ratio of 1.50.