A field investigation was conducted at AICRP on Weed Management Farm, Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola. The experiment was laid out in a randomized block design with three replications and twelve treatments. Among the herbicidal treatments, diclosulam 84% WDG 0.026 kg/ha and sulfentrazone 28% + clomazone 30% WP 0.725 kg/ha (ready mix) as pre-emergence were found effective in controlling sedges, monocot and dicot weeds across the crop growth period along with lowest weed dry matter accumulation, maximum weed control efficiency, lowest weed index and higher seed yield and economics in soybean. Mulching with wheat straw 5t/ha recorded statistically comparable yield over the application of post-emergence herbicide treatments.