Field experiments were conducted to select suitable pre- and post-emergence herbicides for the control of Echinochloa colonum in rice. Treatments consisted of herbicide, viz. unweeded control, two hand weeding at 20 and 40 DAT/DAS, (PE) application of premixed pretilachlor 6% + bensulfuron-ethyl 0.6% GR 10 kg /ha at 3 DAT + hand weeding on 40 DAT/DAS, (PE) application of pre-mixed pretilachlor 6% + pyrazosulfuron-ethyl 0.15% GR 10 kg/ha at 3 DAT + hand weeding on 40 DAT/DAS, (PE) application of pre-mixed pretilachlor 6% + bensulfuron-ethyl 0.6% GR 10 kg/ha at 3 DAT with PoE application of bispyribac-sodium 10% SC 200 mL/ha on 20 DAT, (PE) application of pre-mixed pretilachlor 6% + pyrazosulfuron-ethyl 0.15% GR 10 kg/ha at 3 DAT with PoE application of bispyribac-sodium 10% SC 200 mL/ha on 20 DAT. Significantly lesser weed density (66.4/m2), dry weight (80.8 g/m2) and higher weed control efficiency (82.9%) were recorded with PE application of premixed pretilachlor 6% + bensulfuron-methyl 10 kg/ha at 3 DAT + PoE application of herbicide bispyribac-sodium 10% SC 200 mL /ha on 20 DAT than other treatments at 45 DAT. Significantly higher dry matter production (6.10 t/ha), more number of productive tillers (382/m2) and filled grain/panicle (173) higher grain yield of 5.68 t/ha, mean net returns (  50475/ha) and benefit cost ratio of 2.52 were recorded in PE application of pre-mixed pretilachlor + bensulfuron-methyl 10 kg/ha on 3 DAT + PoE application of herbicide bispyribac-sodium 200 mL /ha on 20 DAT than other treatments. Thus, it could be concluded that PE application of pre-mixed pretilachlor + bensulfuron-methyl 10 kg/ha on 3 DAT + PoE application of herbicide bispyribac-sodium 200 mL/ha on 20 DAT controlled the Echinochloa colona effectively and produced higher productivity and profitability of rice in transplanted condition.