An experiment was carried out during 2021-22 at the Norman E. Borlaug Crop Research Center, G. B. Pant University of Agriculture and Technology, Pantnagar, Udham Singh Nagar District, Uttarakhand to evaluate the effects of sequential and tank mix application of pre- and post-emergence herbicide on weed growth and performance of maize. Among the diverse weed flora observed, Eleusine indica L., Digitaria sanguinalis L., Echinochloa colona L. and Eragrostis japonica L. were dominant grassy weeds, where Phyllanthus niruri L., Commelina benghalensis L., Cucumis melo L. and Cleome viscosa L. were major broad-leaved weeds. Cyperus rotundus L. was the only sedge, where Eleusine indica dominated in the field during entire crop growth period. Chemical weed management through either sole application of topramezone and tembotrione or tank-mix application with atrazine recorded almost similar grain yield along with weed free check. The single tank mix application of atrazine - 0.75 kg/ha long with either tembotrione 120 g/ha or topramezone 25.2 g/ha at 15 DAS as single application can be recommended as a cost-effective method of weed control in maize owing to reduced weed biomass by 57.0 and 58.7%, respectively over weedy plot at 40 DAS while increased the grain yield by 41.6 and 46.7%, respectively under the respective treatments.