Ginger (Zingiber officinale) is highly susceptible to weed infestation because of its slow initial growth. The weed problem severely influences crop productivity and economic returns. Mostly the weed control strategies rely on the manual method which is costly and time-consuming.  Therefore, the current investigation was carried out at the central research farm of Odisha University of Agriculture and Technology, Bhubaneswar, Odisha, India in 2014-2016 to find out the effective and feasible methods for weed control in ginger. Nine treatments which included the use of pendimethalin, oxyfluorfen, pendimethalin followed by (fb) hand weeding, oxyfluorfen fb hand weeding, glyphosate, glyphosate + pendimethalin, glyphosate + oxyfluorfen, 4 hand weeding and unweeded control. Among the treatments, tank mix application of glyphosate + pendimethalin was most effective in controlling weeds with high weed control efficiency (53.8%), minimum weed index (1.09%) and weed persistence index (0.49) as compared to other treatments. Pre-emergence application of glyphosate + pendimethalin also resulted in the highest rhizome yield 27.2 t/ha and B: C of 3.78. Hence, tank mix of Glyphosate 0.80 kg/ha + pendimethalin 1.5 kg/ha applied after mulching and just before emergence of sprouts of ginger is a remunerative method in controlling weeds effectively and giving highest yield in Coastal zone of Odisha.