A field investigation was carried out during rainy (Kharif) 2022 at the Instructional Farm, Rajasthan College of Agriculture, Maharana Pratap University of Agriculture and Technology, Udaipur, India (Sorghum bicolor (L.) Moench). The study involved twelve treatments, including pre-emergence application of atrazine and bentazone, both either alone or in combination and atrazine in combination with varying doses of 2,4-D dimethylamine salt, mesotrione and topramezone as well as mechanical and hand weeding practices. and it was found that application of atrazine 500 g/ha PE fb mechanical weeding at 30 DAS registered the lowest density and dry matter of monocot, dicot and total weeds at 30 DAS (0.00) along with highest grain yield (3.88 t/ha), net return ( 82966/ha) and B C ratio (2.57). this treatment further registered a gain of 70.6 and 92.7% gain in grain yield and net return over weedy check.