Climate change is a natural phenomenon in earth’s environmental system and used to happen over hundreds or thousands of years, but now it is happening within few decades due to increasing human population and associated activities which are responsible for production of more CO₂, methane, N₂O and small quantities of HFC’s. This is expected to increase because the projected global population is 11.2 billion by the end of 21st century from the present 8.1 billion as on 2024.  Under climate change, increased CO₂ is seen as an advantage for C₃ food crops but concomitant increase in temperature negated this impact favouring C₄ crop production, hence, most weeds which are C₄ in nature are threat to agriculture production. Unlike C₃ cereal crops which are the staple foods, millets being C₄ have advantage to compete with C4 weeds and millets are more nutritious and drought tolerant. It is a real challenge to plant scientists to sustain and increase the food production. Hence, in this review an attempt is made to critically evaluate existing literature and provide insights to the researchers and policy makers to promote the millets to meet the food and nutritional security for the ever growing population.