In Moradabad District of Uttar Pradesh (India), livestock is an important agricultural industry that provides financial revenue to farmers and rural communities. Weeds, or undesired plants that compete with agricultural plants, have an impact on crops both in terms of quantity and quality. From October 2021 to December 2022, the current research work investigates the ethno-veterinary practices of 58 weed species from various blocks of Moradabad, focusing on rural regions. The data came from locals such as owners of land, elderly people, agricultural workers, veterinary professionals, vaidyas (ayurved medicines doctor and hakims (Unani doctors). A wide range of agricultural locations were studied with the assistance of local intermediate and degree college students in the concern areas. The current method of classification, the Angiosperm Phylogeny Group-IV system for plant taxonomy, classified weed species into several APG-IV families and grades were followed. Poaceae, Apocynaceae, Asteraceae, Amaranthaceae, and Euphorbiaceae were categorised among the top five APG-IV weed families. Weeds were mostly connected to Lamiids, Fabids, Commelinids, Superasterids, Campanulids, Malvids, Rosids, Eudicots, Monocots, and the ANA Grade of the APG-IV. The most common livestock ailments were skin, galactogogue, dysentery, diarrhea, eye complications, placenta ectomy, constipation, maggot, and mouth infection, for which different weed species were used.  The majority of weeds were herb, shrub, undershrub, creeper, and climber life forms.