An experiment was conducted at CSK Himachal Pradesh Krishi Vishvavidyalaya, Palampur during the kharif seasons of 2021 and 2022, to evaluate the weed management efficacy and rice nutrient uptake as influenced by pyrazosulfuron-ethyl 8.4% + oxaziclomefone 20% WP (pyrazosulfuron-ethyl and + oxaziclomefone)  (ready-mix) in transplanted rice. The pre-emergence application (PE) of pyrazosulfuron-ethyl + oxaziclomefone  at 21+50 g/ha was at par with its higher dose of 26.25+62.5 g/ha and also with weed-free check in significantly lowering total weed density and biomass at 30 and 45 days after transplanting with higher weed control efficiency and lower weed index. Lower removal of N, P and K by total weeds, higher uptake of N, P and K by rice crop, higher rice grain yield and straw yield were also recorded with pyrazosulfuron-ethyl + oxaziclomefone 26.25+62.5 and 21+50 g/ha, which were comparable to the uptake done by rice in weed free. Thus, pyrazosulfuron-ethyl + oxaziclomefone 21+50 g/ha PE was proved to be the most effective option for controlling weeds efficiently and producing higher rice productivity in transplanted rice.