A study was carried out during 2022 and 2023 in Raipur, Chhattisgarh with an objective to study the effect of sequential pre-emergence application (PE) followed by (fb) post-emergence application (PoE) of herbicides on weed management and grain yield of direct-seeded rice (DSR). Weed flora associated with DSR were: Alternanthera sessilis, Cyanotis axillaris, Echinochloa colona, Cyperus iria. Pendimethalin 1000 g/ha PE fb tank mixed bispyribac-sodium 25 g/ha + metsulfuron-methyl + chlorimuron-ethyl ready mix (RM) 4 g/ha PoE at 25 to 30 days after seeding (DAS) reduced weed density with higher rice plant height, leaf area and maximum rice grain yield, which was comparable with pendimethalin 1.0 kg/ha PE fb penoxsulam + cyhalofop-butyl (RM) 135 g/ha PoE 25-30 DAS and hand weeding twice at 30 and 60 DAS. It was concluded that pendimethalin 1.0 kg/ha PE fb bispyribac-sodium 25 g/ha + metsulfuron-methyl + chlorimuron-ethyl (RM) 4 g/ha tank mix PoE at 25-30 DAS effectively managed weeds in direct-seeded rice which resulted in maximum rice growth and yield as well as maximum net return and B:C ratio.