This study was conducted at the Agricultural Research Farm, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh (U.P.) during the Kharif season of 2023-24. The aim was to evaluate the efficacy of saflufenacil against weeds in soybean (Glycine max L.). A randomized block design (RBD) was used with seven treatments, viz. four dosage rates of saflufenacil at 16, 22, 25, and 50 g/ha, diclosulam 26 g/ha, hand weeding twice at 20 and 40 days after sowing (DAS), and unweeded check, replicated thrice. Hand weeding at 20 and 40 DAS resulted in maximum weed control, growth of soybean and highest seed yield, amongst the tested treatments. Saflufenacil 50 g/ha caused the lowest weed density, weed biomass, and highest weed control efficiency which improved soybean growth parameters, yield-related characteristics and increased yield of soybean amongst saflufenacil dosage rates tested.