A field experiment was conducted at Pantnagar during winter season 2005-06 and 2006-07 to study effect of rates of herbicide mixture clodinafop-propargyl 15% + metsulfuron-methyl 1% (UPH-206) for control of mixed weed flora in wheat (Triticum aestivum L.). Grassy weeds such as Phalaris minor, Avena fatua and broad-leaved weeds, viz., Chenopodium album, Melilotus spp., Medicago denticulata, Vicia sativa, Rumex spp., Anagallis arvensis, Coronopus didymus, Lathyrus aphaca and  Polygonum plebejum  were effectively controlled by application of UPH-206  500 g product/ha. The highest grain yield (4.17 t/ha) of wheat was also obtained with the post-emergence application of UPH-206 500 g product/ha being at par with UPH-206 400 g product/ha, and hand weeding at 35 and 55 DAS, but significantly higher than sulfosulfuron, clodinafop and isoproturon at recommended rates. No residual effect of UPH 206 at any of doses tested was obtained on succeeding crops of blackgram and maize.