An experiment was conducted at Oilseeds Research Station, Jalgaon during 2007 to 2009 in order to control groundnut associated weed growing in Kharif season. An experiment was done with seven treatments of pre and post-emergence herbicides comprising weedy cheek and weed free check replicated thrice in randomized block design (RBD) on medium clay loam soils with pH 8.1. The various weeds observed in groundnut field during Kharif season were, Amaranthns viridus, Parthenium hysterophorus, Acalypha indica, Cyperus rotundus , Cynodon dactylon, Phyllanthus niruri, Commelina spp., Eragrostic sp., Celosia argenia and Euphorbia sp. Among the grasses, Cynadon dactylon was predominant and among the sedges Cyperus rotundus was predominant. Among the different herbicides, pre-emergence application of pendimethalin 1.0 kg/ha + post-emergence application of imazethapyr 75 gm/ha at 20 DAS recorded maximum weed control efficiency (74%), minimum weed population (42.67/m2) and weed day matter (185 g/m2). The same treatment combination recorded significantly higher dry pod yield (1997 kg/ha), gross returns (46445/ha) net returns (28705/ha) and B: C ratio 2.44.