A field experiment was conducted at Chatha, Jammu during winter season of 2004-05 and 2005-06 to study the effect of different herbicides and its mixtures on weeds and yield of wheat (Triticum aestivum). Unchecked weeds growth caused 40.3% reduction in grain yield of wheat. Application of sulfosulfuron (25 g) + 2,4-D (500 g/ha) reduced weed population and  biomass significantly and thereby caused increase in crop growth and grain yield of wheat. This was at par with tank-mix application of clodinafop (60 g) + metsulfuron-methyl (2 g/ha), isoproturon (750 g) +2,4-D (500 g/ha) and fenoxaprop (120 g) + metribuzin (100 g/ha). Maximum grain yield was recorded in weed-free (5.05 t/ha), but the highest B:C ratio was observed with isoproturon+2,4-D (1.79). There was a significant positive correlation between N uptake by crop and grain yield of wheat (0.99), but a negative correlation was observed between grain yield and density and N removal by weeds.