A field experiment was conducted during Rabi season of 2009-10 at College of Agriculture, Pune to study the eficacy of different herbicides on growth and productivity of wheat. The growth  attributes of wheat crop in terms of plant height, number of tillers/plant, leaf area index, and dry matter accumulation/plant were maximum with weed free check. Among the herbicide treatments, post-emergence application of sulfosulfuron 25 g/ha recorded higher values of all these growth attributes characters and were on par with hand weeding at 30 DAS and application of metribuzin 175 g/ha. However, substantial reduction in growth characters was observed in weedy check. The values of yield attributes were higher in magnitude in weed free check treatment. The next best treatment was application of sulfosulfuron 25 g/ha. Amongst the weed control treatments, application of sulfosulfuron 25 g/ha, recorded maximum grain and straw yield of 3.71 and 4.78 t/ha, respectively, as compared to other treatments. However, substantial reduction in growth and yield attributes and yield were observed in weedy check.