A field experiment was carried out at Gwalior during Kharif season of 2010 to access the effect of weed management practices to sesame on seed yield and nutrient uptake by crop and weeds and net returns. Two hand weeding at 15 and 30 DAS registered highest yield (1190.22 kg/ha) and net return ( 42391/ha) in addition to higher NPK uptake by crop and lower NPK uptake by weed. Among herbicidal treatments application of trifluralin 0.75 kg/ha followed by one hand weeding at 30 DAS was found superior for yield, NPK uptake by plant and net return. Integration of herbicides viz., trifluralin, pendimethalin, quizalofop ethyl and clodinafop with one hand weeding at 30 DAS was found more effective as compared to their alone use. NPK removed by weeds was heighest in weedy check and lowest in two hand weeding followed by trifluralin 0.75 kg/ha integrated with one hand weeding at 30 DAS.