A field experiment was conducted during Kharif seasons of 2010 at JNKVV, Jabalpur to study the efficacy of bispyribac-sodium and other herbicides against weeds in drilled rice.  The field was infested with grassy weeds viz., Echinochloa colona, Dinebra retroflexa, Cyperus iria, Eclipta alba and Phyllanthus niruri. The efficacy of bispyribac-sodium as post- emergence was significantly superior when applied at 80 g/ha over other herbicides. However, the application of bispyribac-sodium 20 g/ha was more remunerative. Among the herbicidal treatments bispyribac-Na 80 g/ha recorded maximum grain yield (4.59 t/ha) which was at par with other doses of bispyribac-Na except 10 g/ha and significantly higher as compared to cyhalofop-butyl and butachlor.