Imazethapyr, quizalofop-P-ethyl, pendimethalin and alachlor at 0.1, 0.06, 1.0 and 2.0 kg/ha, respectively, alone and with hand weeding 40 DAS were compared with one and two hand weedings against mixed weed flora in clusterbean. All the weed control treatments significantly reduced the dry weight of complex weed flora, although they differed in their effect on monocot and dicot weeds. Imazethapyr alone and with hand weeding 40 DAS effectively controlled both monocot and dicot weeds, while quizalofop-ethyl controlled only monocot weeds. Uninterrupted weed growth depleted 108.5 kg N, 15.8 kg P and 151.6 kg K/ha, while such losses were lowest with two hand weedings 20 and 40 DAS. Highest grain yield was obtained with weed free check (1840 kg/ha) followed by two hand weedings (1720 kg/ha) and imazethapyr 100 g/ha+hand weeding 40 DAS (1711 kg/ha) and it was significantly higher than all other treatments. Maximum uptake of N (133.8 kg/ha), P (32.5 kg/ha) and K (135.1 kg/ha) by clusterbean was recorded in two hand weedings (20 and 40 DAS), while in weedy check plots N, P and K uptake by crop was 40.6, 9.8 and 41.1 kg/ha, respectively.