Clodinafop 60 g/ha and metsulfuron methyl 4 g/ha + surfactant 0.02% alone, combinations of clodinafop and metsulfuron + surfactant at the similar and double dose and isoproturon + 2, 4-D were evaluated against complex weed flora in wheat during 2007-08 and 2008-09. Phalaris minor, Avena ludoviciana and Lolium temulentum were the major grassy weeds. Vicia sp., Anagallis arvensis and Lathyrus aphaca were among the broad-leaved weeds found growing in association with wheat crop. All the herbicidal treatments significantly reduced the dry weight of weeds. Tank mixture of clodinafop 60 g/ha + metsulfuron 4 g/ha and clodinafop 120 g/ha + metsulfuron 8 g/ha with and without 0.2% surfactant provided excellent control of weeds and produced significantly higher grain yield of wheat. Weeds caused 55.7% reduction in wheat grain yield.