A field experiment under on farm trials programme of KVK, was conducted in farmers field during rabi 2005-06 and 2006-07 on wheat (Tricitum aestivum L.) crop cv. GW-273 to evaluate the efficiency of two herbicide 2,4-D and isoproturon and their tank mixture. Phalaris minor among the monocot weeds and Lathyrus aphaca among dicot were the major weeds in the demonstration fields, Post emergence application of 2,4-D 0.75 kg/ha + isoproturon 1.0 kg/ha at 25-30 days after sowing (DAS) gave maximum grain yield (3646 kg/ha) followed by the alone application of isoproturon 1.0 kg/ha at 25-30 DAS with gain yield (3222 kg/ha) and 2, 4-D 0.75 kg/ha at 25-30 DAS (2910 kg/ha). The application of 2,4-D + isoproturon increased the grain yield by 35.4% over control and 19% and 26.8% over individual application of 2,4-D and isoproturon, respectively. The application of 2,4-D + isoproturon also resulted higher weed control efficiency (80.4%).