A field experiment was conducted during kharif seasons of 2008 and 2009 at Livestock Farm, JNKVV, Jabalpur, to evaluate the efficacy of imazethapyr against weeds in groundnut. Eight treatments comprising of five doses of imazethapyr 50, 100, 150, 200 and 300g/ha alone, combined application of imazethapyr + chlorimuron (100+24 g/ha), hand weeding twice (20 and 40 DAS) including weedy check were laidout in randomized block design with three replications. The experimental field was infested with monocot weeds like Cyperus iria (44.08%) Echinochloa colona (30.51%) and Dinebra retroflexa (25.39%) at 40 DAS during both the years among the sedges and grassy weeds. The efficacy of imazethapyr at lowest rate (50 g/ha) was poor, which improved with the increase in application rates from 150 to 300 g/ha. However, combined application of imazethapyr at lower rate 100 g/ha with chlorimuron 24 g/ha paralyzed the weed growth identically (98.1%) to that of hand weeding twice (98.6%) and attained the superior values of yield attributes (13.5 pods/plant, 2.4 kernels/pod) as well as higher pod and haulm yields (12.83 and 21.21 q/ha). The latter treatment was also found more remunerative as it fetched the maximum values of net monetary returns (Rs 14096/ha) and benefit:cost ratio (1.8) and surpassed the recommended practice of weed control viz., hand weeding twice which recorded the inferior values of net monetary return (Rs 10194/ha) and B:C ratio (1.4) due to more cost of weed control.