Effect of tillage methods and weed management practices on weed infestation and yield of wheat was studied during 2002-2003 and 2003-2004. Density and dry weight of total weeds recorded lower under zero till and bed planting system as compared to conventional tillage for initial year. In second year, it was again recorded lowest under zero tillage, but increasing trend was observed under bed planting situation. Number of spikes as well as grain yield was not influenced by tillage methods during first year, but was found maximum under zero till situation in the next year. Excellent suppression of weeds and thereby higher yields were obtained under two hand weeding under conventional system. Under weedy situation, zero till system was found better because of lesser weed emergence.