A field experiment was conducted during rabi 2007-08 at NRC-Weed Science, Jabalpur (M.P.) to assess the effect of tillage and weed control practices on weed flora and yield of wheat in direct seeded rice-wheat cropping system. Yields were not influenced by any of the tillage packages adopted in wheat. But chemical weed control (clodinafop 0.060 fb 2,4-D 0.50 kg/ha) or integrated weed management practice (IWM) (clodinafop 0.060 fb 2,4-D 0.50 kg/ha + 1 HW at 40 DAS) after all the tillage packages increased grain and straw yields of wheat compared to weedy check plots. IWM practice (clodinafop 0.060 fb 2,4-D 0.50 kg/ha + 1 HW at 40 DAS) produced significantly higher grain yield of wheat than chemical control alone (clodinafop 0.060 fb 2,4-D 0.50 kg/ha). benefit per rupee of investment was higher in plots receiving clodinafop fb 2, 4-D in zero tilled wheat after conventional tillage in rice as well as IWM in wheat under zero tilled wheat after zero tillage in rice. Zero tilled wheat after zero tillage in rice had lower weed density and dry weight of weeds than other tillage (clodinafop 0.060 fb 2,4-D 0.50 kg/ha + 1 HW at 40 DAS) packages adopted in wheat after rice. Similarly post-emergence application of clodinafop 0.060 fb 2,4-D 0.50 kg/ha or integrated weed management in wheat, was found effective in curtailing the population including dry weight of dominant grassy and dicot weeds.