The experiment was conducted at the Research Farm of the Punjab Agricultural University, Ludhiana in rabi seasons of 2005-06 and 2006-07 to study the efficacy of tank mix application of 2, 4-D, carfentrazone and metsulfuron with isoproturon in managing weeds of irrigated barley. Minimum weed dry weight was recorded in isoproturon 1000 g+metsulfuron 4 g/ha which was statistically on par with isoproturon 1000 g/ha, isoproturon 1000 g+carfentrazone 20 g/ha and isoproturon 1000 g+2, 4-D 500 g/ha during 2005-06. In 2006-07, minimum weed dry weight was recorded in two hand weedings which was statistically on par with isoproturon 1000 g+metsulfuron 4 g/ha, isoproturon 1000 g/ha, isoproturon 1000 g+carfentrazone 20 g/ha, and isoproturon 1000 g+2,4-D 500 g/ha. Highest test weight and barley grain yield were recorded in isoproturon 1000 g+metsulfuron 4 g/ha which were statistically on par with isoproturon 750 g+metsulfuron 4 g/ha, isoproturon 750 g+2,4-D 500 g/ha, isoproturon 1000 g+2, 4-D 500 g/ha and two hand weedings. The highest net returns of Rs. 29063 with isoproturon 1000 g+metsulfuron 4 g/ha and Rs. 39581 were recorded in isoproturon 1000 g+2, 4-D 500 g/ha as tank mix in 2005-06 and 2006-07, respectively.