A field experiment was carried out at Agronomy Farm, B.A. College of Agriculture, Anand Agricultural University, Anand (Gujarat) during kharif season of the year 2008. The experiment was laid out in randomized block design (RBD) with four replications and twelve weed control treatments viz., imazethapyr 75 g/ha (T₁), imazethapyr 75 g/ha fb chlorimuron ethyl 8 g/ha (T₂), imazethapyar 75 g/ha fb hand weeding 30 DAS (T₃), fenoxaprop-p-ethyl 75 g/ha (T₄), fenoxaprop-p-ethyl 75 g/ha fb chlorimuron ethyl 8 g/ha (T₅), fenoxaprop-p-ethyl 75 g/ha fb hand weeding at 30 DAS (T₆), quizalofop ethyl 75 g/ha (T₇), quizalofop ethyl 75 g/ha fb chlorimuron ethyl 8 g/ha (T₈), quizalofop ethyl 75 g/ha fb hand weeding at 30 DAS (T₉), hand weeding at 20 and 40 DAS (T₁₀) inter fb hand weeding at 20 and 40 DAS (T₁₁) and weedy check (T₁₂), with the objectives to compare different weed management practices and effect on growth and yield of soybean. Application of post emergence herbicide in conjunction with hand weeding was found effective for control of monocot, dicot and sedges at harvest in kharif soybean. Treatment T₁₁, registered higher seed (2251 kg/ha), straw yield (3756 kg/ha) and harvest index (34.72%) followed by treatments T₁₀, T₉ (quizalofop ethyl 75 g/ha as PoE fb hand weeding at 30 DAS) and T₆ (fenoxaprop-p-ethyl 75 g/ha as PoE fb hand weeding at 30 DAS), respectively. Moreover, cost benefit ratio was also recorded higher (1:3.67) under the treatment T , followed by treatment T₁₀, T₃, and T₆.