Field experiment was carried out in Mogra Block Farm, Hooghly, West Bengal in pre-kharif 2005 and 2006 to evaluate the relative efficacy of different herbicides alone and in combination with hand weeding. Results revealed that pre-emergence application of herbicides integrated with one hand weeding were superior to their sole application in controlling Trianthema portulacastrum and increasing seed yield of sesame. Butachlor with one hand weeding proved its superiority over rest of the treatments in respect of weed control efficiency, seed yield and net return. Farmers' practice recorded at par result with butachlor integrated with one hand weeding in seed yield of sesame