Herbicides are the most effective and economic among the weed management practices. Use of herbicide is rapidly increasing in the world including India. Herbicides have revolutionized the weed management in world agriculture. Along with the advantages there are some inadvertent disadvantages like shift in weed flora, herbicide resistance and environmental concern. Development of resistance against the herbicides in targeted species is the most prominent among them. Herbicide resistance is a worldwide phenomenon and number of resistant biotypes of weeds is increasing at an alarming rate. Recently, almost one dozen species have been reported to be resistant against Monsanto’s very potent broad spectrum herbicide glyphosate which has now become a key issue for all stakeholders. Sometimes the use of the term herbicide resistance is misleading. Before calling it herbicide resistance, the factors for poor efficacy of herbicide should be sincerely evaluated. It is essential to properly understand the herbicide resistance, its development and mechanism to tackle the problem. In this paper an attempt has been made to review of up to date information on current status of herbicide resistance in the world – development of resistance, factors controlling the development of herbicide resistance in weeds, resistance mechanisms, integrated approach of herbicide resistance management and lastly basic research and facilities required for better understanding of herbicide resistance and its management.