Parthenium contact cause skin allergy, pollen leads to breathing problems in sensitive human and if deposited on stigmatic surface fruits gets aborted in brinjal. Parthenium harbors organisms of virus diseases and infect the crop later. Managing the Parthenium is absolutely essential but costly. Non-availability of timely labour force and the awareness of chemical pollution causes dilemma of herbicide usage. Alternative technique to manage Parthenium weed is a welcome challenge.Aqueous extracts of fresh or dry leaves (1%) of Lantana camara and Hyptis sulvelolensis suppressed germination of Parthenium more than that by Cassia uniflora extracts. Mulching of these botanical agents (10 t/ha) suppressed Parthenium till 60 DAS, but stimulated the growth of sunflower and tomato, respectively. Mulching of fresh or 30 days deposited materials suppressed the germination and growth of Parthenium. Soil sterilization enhanced the allelochemical efficacy of botanical agent indicating the role of soil microbes in degrading the allelochemicals.