Two field experiments were conducted at Chaudhary Charan Singh Haryana Agricultural University, Hisar during winter season of 2005-06 and 2006-07 to study the bioefficacy and phytotoxicity of herbicide UPH-206 (Clodinafop propargyl 15% + Metsulfuron 1%) for the control of complex weed flora in wheat (Triticum aestivum L.). Dominant grassy weeds, viz., little seed canary grass (Phalaris minor Retz.), wild oat (Avena ludoviciana and broadleaf weeds like common lambsquartres (Chenopodium album L.), yellow sweet clover (Melilotus indica All), golden dock (Rumex dentatus L.) and swine grass (Coronopus didymus L.) were effectively controlled by post emergence (35 DAS) application of UPH-206, a ready-mix formulation of clodinafop 15% + metsulfuron 1%) at 60 + 4 g /ha. Maximum grain yield (4890 and 4894 kg/ha) was obtained with the use of UPH-206 + S at 75+5 g/ha which were at par with weed free check and ready mixture of sulfosulfuron + metsulfuron and UPH 206 + S at 60 + 4 g/ha but significantly higher than clodinafop and sulfosulfuron. No carry over effect of this herbicide at any of doses tested was observed on succeeding sorghum crop