An experiment was conducted during the rainy seasons of 2003 and 2004 at Agronomy Research Farm, Allahabad Agricultural Institute-Deemed University to assess the response of rice and associated weeds to establishment methods, fertility levels and weed management practices. The experiment was laid out in three factor randomized block design comprising two establishment methods (direct wet seeding and transplanting), three levels of fertility viz., 80, 40, 40; 100, 50, 50 and 120, 60, 60 NPK kg/ha and four weed management practices viz., (W1) anilofos @ 0.4 kg a. i./ha, (W2) butachlor @1.5 kg a. i./ha, (W3) two hand weedings and (W4) weedy check. These comprised 24 treatments, which were replicated thrice. Results revealed that transplanting method of rice establishment recorded lowest number of weeds and weed dry weight resulting in significantly higher grain yield. The weed intensity and weed dry weight increased with the increase in fertility level and was maximum with 120, 60, 60 NPK kg/ha. Anilofos and butachlor brought down weed intensity, weed dry weight and NPK uptake but were not as efficient as two hand weedings. The higher net profit and BCR was observed in direct seeded plots treated with high fertilizer dose of 120, 60, 60 NPK kg/ha and anilofos. The maximum weed control efficiency was observed in transplating between establishment methods, low fertilizer dose of 80, 40, 40 NPK kg/ha between fertility levels and anilofosn among weed management practices at all the growth stages of crop. The maximum weed index of 68% was observed in weedy check plots.