A field experiment was conducted at the Product Testing Unit, JNKVV, Jabalpur during Kharif season 2013 and 2014 to adjudge the efficacy of propaquizafop and imazethapyr mixture against weeds in soybean. Grassy weeds were predominant (76.25%) in the experimental field compared with broadleaved weeds (23.75%). However, Echinochloa colona (33.90%) and Dinebra retroflexa (23.90%) were predominant in soybean but, other weeds (Cyperus rotundus, Cynodon dactylon, Alternanthera philoxeroides, Eclipta alba and Mollugo pentaphylla) were also present. Post-emergence application of propaquizafop (75 g/ha) alone curbed only grassy weeds. However, its efficacy was improved when applied in combination with imazethapyr being higher under propaquizafop + imazethapyr mixture applied at 53 + 80 g/ha or higher rate (56 + 85 g/ha). Yield attributing characters and yield were superior under propaquizafop + imazethapyr mixture applied at 56 + 85 g/ha followed by 53 + 80 g/ha which were comparable to hand weeding twice at 20 and 40 DAS.