A field experiment was conducted during 2011 at Anand, Gujarat to study the bio-efficacy of different herbicides against weeds of blackgram grown in Kharif season. Density and dry weight of weeds were significantly reduced by twice hand weeding carried out at 20 and 40 DAS than that of recorded in other treatments except pre-emergence application of pendimethalin 500 g/ha fb IC + HW at 30 DAS, quizalofop-ethyl 38 g /ha as POE fb IC + HW at 30 DAS, imazethapyr 50 g/ha as POE fb IC + HW at 30 DAS, oxyfluorfen 100 g/ha as PE fb IC + HW at 30 DAS) and fenoxaprop-p-ethyl 50 g/ha as POE fb IC + HW at 30 DAS. Twice hand weeding treatment was found superior to other treatments in respect of reducing the density and dry weight of weeds and recording higher seed and haulm yields.