To study the efficacy of pendimethalin alone or in combination with neem cake and castor cake, seed treatment with various herbicides and post-emergence application of glyphosate at very low concentrations, field experiments were conducted during Rabi season of 2008-09 and 2009-10, at village Obera, Distt. Bhiwani and Dry land Research Area of CCS HAU Hisar (Haryana). Feasibility of adoption of results of study was tested by multi location field trials conducted through farmers’ participatory approach in different parts of state during 2010-2013. Pre-emergence, pre-plant incorporation or herbigation of pendimethalin along with hoeing as well as use of organic manures, viz. castor cake and neem cake proved ineffective in minimizing density of this weed. Seed coating of mustard seeds with 1.0 ppm of chlorsulfuron or triasulfuron gave 70-98% control of Orobanche aegyptiaca but efficacy of seed treatment with sulfosulfuron was poor. Post emergence application of glyphosate at 25 and 50 g/ha with 1% solution of (NH4)2SO4 at 25 and 55 DAS showed promise with 63-100% control of this weed not only in experimental fields but in large scale farmers’ fields. Glyphosate dose range is very limited. Over dosing of glyphosate, resulted in 15-35% toxicity to mustard in terms of marginal leaf chlorosis, slow leaf growth and bending of apical stems and stunting with yield penalty. Bleaching of few leaves of mustard occurred with 50 g/ha dose at 55 DAS, which also recovered within 20 days resulting with no loss in yield.