A field experiment was carried out at Norman E. Borlaug Crop Research Centre of G.B.P.U.A&T, Pantnagar during Rabi seasons of 2010-11 and 2011-12 to test the efficacy of different dosses of metribuzin 42% + clodinafop propargyl 12% WG against weeds in wheat. The soil of the experimental field was clay loam in texture, medium in organic carbon (0.67%), available phosphorus (29.6 kg/ha) and potassium (176.4 kg/ha) with pH 7.2. Results revealed that metribuzin + clodinafop-propargyl at 500-600 g/ha were as effective as two hand weeding at 30 and 50 DAS in reducing the weed density of Phalaris minor and Chenopodium album, Cornopus didymus, Melilotus spp., Rumex spp. and Fumaria parviflora at 30 and 60 days after application as compared to rest treatments. Maximum grain yield was recorded in metribuzin + clodinafop-propargyl WG at 600 g/ha which was statistically at par with its lower dose of 500 g/ha due to effective control of grassy and broad-leaved weeds in wheat.